A new diagnostic and therapeutic approach fibrinolysis and hemorrhage.

By J. C. HEUSON, W/. PEERS AND H. J. TAGNON I HE FOLLOWING STUDY gives evidence that the enzyme present in the plasma of a patient with acute fibrmnolysis was able to digest a protein substrate different from fibrinogen or fibrin. On tile other hand, this enzyme was found to l)e markedily inhibited in vitro by the soy bean trypsin inhibitor ( S.B.I. ) . On tile basis of this observation, an attempt was made to treat the patient by means of the intravenous administration of S.B.I., and the results of this treatment are reported here. This study represents the first observation of the treatment of fibrmnolysis of shock in humans by means of S.B.I.